Actin-based Motility
Gene co-expression module in Gamma-delta T cells
| Category | Cytoskeletal |
|---|---|
| Genes | 22 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 22 genes have a known function matching the annotation |
Why this annotation
Hub genes strongly converge on actin cytoskeleton remodeling and cell migration: APBB1IP (RIAM, integrin-talin-actin linker essential for inside-out integrin activation and migration), OSTF1 (osteoclast-stimulating factor, promotes actin ring formation), EVL (Ena/VASP-like, actin polymerization at leading edge), VASP (actin dynamics, lamellipodia), RHOC (Rho GTPase, cytoskeletal contractility), CORO1B (coronin-1B, actin branching), TMSB4X (thymosin-beta4, G-actin sequestration). HMOX2 (heme oxygenase) and CTSD (cathepsin D) add oxidative/lysosomal context. STXBP2 links to cytotoxic granule exocytosis. This module represents an actin-based motility and cytoskeletal remodeling program consistent with gd_T cell migration and effector function.
Genes
APBB1IP, CD58, COMMD7, CORO1B, CTSD, EVL, FDFT1, HMOX2, OSTF1, PCID2, RAB33A, RABAC1, RHOC, SEC11A, SKAP1, SNX6, SRI, STAMBP, STXBP2, TMSB4X, TTC1, VASP
Most correlated modules
- Metabolic Housekeeping · correlation 0.82
- Ubiquitin-Proteasome Trafficking · correlation 0.80
- DNA Damage Repair · correlation 0.79
- Mitoribosome Small Subunit · correlation 0.78
- DNA Repair Housekeeping · correlation 0.78
- Lysosomal Biogenesis · correlation 0.77
- Mitochondrial OxPhos · correlation 0.75
- Mitochondrial Translation · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.