PDXK — Pyridoxal kinase
PDXK belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PDXK's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Proteasome/translation Protein processing & ER | ANP32E, CDC123, EIF4E, EIF5B, EMC8, MRPL20, NME7, PKM +9 more | View in SCUBA |
| Gamma-delta T cells | ER Stress Response Stress | ATP1B3, ATP2A2, BACH1, CPD, EIF2AK3, FAM118A, G3BP2, GRK5 +13 more |
About the gene
| Synonyms | C21orf124, C21orf97, FLJ21324, FLJ31940, MGC15873, PKH, PNK, PRED79 |
|---|---|
| Chromosome | 21: 43719094-43762307 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Kinase, Transferase |
Function
Catalyzes the phosphorylation of the dietary vitamin B6 vitamers pyridoxal (PL), pyridoxine (PN) and pyridoxamine (PM) to form pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), respectively (Probable). PLP is the active form of vitamin B6, and acts as a cofactor for over 140 different enzymatic reactions.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.