ER Stress Response
Gene co-expression module in Gamma-delta T cells
| Category | Stress |
|---|---|
| Genes | 22 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 22 genes have a known function matching the annotation |
Why this annotation
EIF2AK3/PERK is the canonical ER stress sensor kinase of the UPR. ATP2A2/SERCA2 (ER calcium pump, ER homeostasis), PTPN1/PTP1B (ER-tethered phosphatase, UPR-regulated), G3BP2 (stress granule nucleator), MKNK2 (MNK2, eIF4E kinase activated under stress), BACH1 (oxidative stress transcriptional repressor), PLIN2 (lipid droplet formation, ER stress-linked), ULBP2 (NKG2D ligand upregulated by ER/genotoxic stress), and EIF2AK3 together constitute a coherent ER stress / unfolded protein response program. Neighbor context with M165 (stress feedback) further supports a stress biology cluster.
Genes
ATP1B3, ATP2A2, BACH1, CPD, EIF2AK3, FAM118A, G3BP2, GRK5, HBP1, IRS2, MKNK2, MRFAP1, PDXK, PIGA, PLIN2, PTPN1, RMND5A, RYBP, SLAIN2, SNN, ULBP2, ZNF571
Most correlated modules
- Chromatin Epigenetic Regulation · correlation 0.93
- Stress Negative Feedback · correlation 0.91
- AHR/NF-κB Survival · correlation 0.86
- TCR Threshold Regulation · correlation 0.84
- Autophagy Stress Response · correlation 0.84
- NF-κB Activation · correlation 0.82
- S-phase Proliferation · correlation 0.79
- cAMP Lipid Signaling · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.