PHGDH — Phosphoglycerate dehydrogenase
PHGDH belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PHGDH's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | PI16+ Fibroblast Identity ECM production | AADACL2, ADAMTSL4, ARHGAP29, C16orf89, CADM3, CD248, CLEC3B, CYP4B1 +10 more | View in SCUBA |
| Smooth muscle cells | Microtubule biogenesis Cytoskeletal | ACOT7, FBXL22, ILF2, LIMS2, NUCB2, PGRMC1, PPP2R1A, TBCB +3 more | View in SCUBA |
About the gene
| Synonyms | PDG, PGDH, SERA |
|---|---|
| Chromosome | 1: 119648411-119744218 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Oxidoreductase |
| Biological process | Amino-acid biosynthesis, Serine biosynthesis |
Function
Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.