Microtubule biogenesis
Gene co-expression module in Smooth muscle cells
| Category | Cytoskeletal |
|---|---|
| Genes | 12 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 6 of 12 genes have a known function matching the annotation |
Why this annotation
Dominated by tubulin isotypes TUBB, TUBB6, TUBB2A and the tubulin-folding cofactor TBCB, indicating a microtubule biogenesis/turnover program; PPP2R1A, LIMS2 (PINCH2, adhesion), FBXL22 (muscle E3 ligase), NUCB2, ACOT7 and PHGDH are peripheral metabolic/adhesion genes explaining the moderate coherence. Elevated TUBB6 is often seen in de-differentiating/synthetic SMCs. Neighbors M17 (housekeeping) and the adhesion modules support a cytoskeletal-remodeling rather than mitotic interpretation (no cyclins or mitotic kinases present).
Genes
ACOT7, FBXL22, ILF2, LIMS2, NUCB2, PGRMC1, PHGDH, PPP2R1A, TBCB, TUBB, TUBB2A, TUBB6
Most correlated modules
- Contractile SMC phenotype · correlation 0.82
- SMC focal adhesion · correlation 0.81
- Basal metabolic housekeeping · correlation 0.80
- Microfibrillar ECM Program · correlation 0.75
- Proliferative Biosynthesis · correlation 0.72
- SMC Contractile Signaling · correlation 0.71
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.