PGRMC1 — Progesterone receptor membrane component 1
PGRMC1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PGRMC1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Glial cells | Glial Vesicle Trafficking Housekeeping | BEX3, CCNI, FKBP1A, HMGN2, ITM2C, PLD3, TCEAL7, TUBB +1 more | View in SCUBA |
| Lymphatic endothelial | Lymphatic Valve Identity Valve formation | ALCAM, C12orf57, C17orf58, CFH, CLDN11, DEGS2, EBPL, EDNRB +13 more | View in SCUBA |
| Smooth muscle cells | Microtubule biogenesis Cytoskeletal | ACOT7, FBXL22, ILF2, LIMS2, NUCB2, PHGDH, PPP2R1A, TBCB +3 more | View in SCUBA |
About the gene
| Synonyms | HPR6.6 |
|---|---|
| Chromosome | X: 119236245-119244466 |
| Predicted location | Membrane, Secreted |
| Essential gene | No |
| Protein class | Predicted membrane proteins, Predicted secreted proteins |
| Molecular function | Receptor |
Function
Component of a progesterone-binding protein complex. Binds progesterone. Has many reported cellular functions (heme homeostasis, interaction with CYPs). Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan (By similarity). Intracellular heme chaperone. Regulates heme synthesis via interactions with FECH and acts as a heme donor for at least some hemoproteins. Forms a ternary complex with TMEM97 receptor and low density lipid receptor/LDLR, which increases LDLR-mediated LDL lipoprotein internalization.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.