FBXL22 — F-box and leucine rich repeat protein 22
FBXL22 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FBXL22's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Smooth Muscle Identity Cytoskeletal | ACTG2, ALDH1B1, C3orf70, CNN1, HSD17B6, JPH2, KCNH2, KCNMB1 +12 more | View in SCUBA |
| Smooth muscle cells | Microtubule biogenesis Cytoskeletal | ACOT7, ILF2, LIMS2, NUCB2, PGRMC1, PHGDH, PPP2R1A, TBCB +3 more | View in SCUBA |
About the gene
| Synonyms | Fbl22, FLJ39626 |
|---|---|
| Chromosome | 15: 63597353-63602428 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Ubl conjugation pathway |
Function
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes ubiquitination of sarcomeric proteins alpha-actinin-2 (ACTN2) and filamin-C (FLNC)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.