PIH1D1 — PIH1 domain containing 1
PIH1D1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PIH1D1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Actin Remodeling Cytoskeletal | AP1M1, APOBEC3C, ATP5PB, CAP1, CAPN1, CAPZB, DBNL, LSP1 +10 more | |
| Innate lymphoid cells | Transcription RNA Processing RNA processing & translation | ARMCX6, BANF1, CCAR1, CLDND1, COMMD1, FEZ2, HELZ, HSBP1 +11 more | View in SCUBA |
About the gene
| Synonyms | DNAAF14, FLJ20643, MOT48, NOP17, Pih1 |
|---|---|
| Chromosome | 19: 49446298-49453497 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Transcription, Transcription regulation |
Function
Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles. Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre- rRNA transcription. Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1. Positively regulates the assembly and activity of the mTORC1 complex.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.