DBNL — Drebrin like
DBNL belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DBNL's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Actin Remodeling Cytoskeletal | AP1M1, APOBEC3C, ATP5PB, CAP1, CAPN1, CAPZB, LSP1, PIH1D1 +10 more | |
| Innate lymphoid cells | ILC1 Lymphocyte Signaling Immune regulation | CDIPT, CNPY3, ENG, IL16, LIMD2, LSM2, MAPKAPK3, PHYKPL +11 more | View in SCUBA |
| Macrophages | Macrophage Proliferation Cell cycle | ALDH16A1, ARL6IP4, BIN2, BRI3BP, CCDC112, CCP110, CD33, CD36 +15 more | View in SCUBA |
| Mucosal-associated invariant T cell | Cellular Housekeeping Housekeeping | AKR7A2, ANP32A, ANXA5, AP1M1, APEX1, APOBEC3C, CDC26, DCK +17 more |
About the gene
| Synonyms | ABP1, HIP-55, SH3P7 |
|---|---|
| Chromosome | 7: 44044640-44069456 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
| Molecular function | Actin-binding |
| Biological process | Adaptive immunity, Endocytosis, Immunity, Transport |
Function
Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes (By similarity). May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.