PPARA — Peroxisome proliferator activated receptor alpha
PPARA belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PPARA's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | PPARA/FXR fatty acid oxidation Lipid metabolism | ALDH18A1, ANO10, CPT1A, DGKD, FAT1, FMO5, NDRG1, NR1H4 +4 more | View in SCUBA |
| Macrophages | Mixed Regulatory Signaling Housekeeping | ADAP2, AKAP11, ARHGAP17, ARHGAP27, BLTP2, BLTP3A, C2CD2L, COG2 +30 more | View in SCUBA |
About the gene
| Synonyms | hPPAR, NR1C1, PPAR |
|---|---|
| Chromosome | 22: 46150521-46243755 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | FDA approved drug targets, Nuclear receptors, Predicted intracellular proteins, Transcription factors, Transporters |
| Molecular function | Activator, DNA-binding, Receptor |
| Biological process | Biological rhythms, Transcription, Transcription regulation |
Function
Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn- glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as a transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.