NDRG1 — N-myc downstream regulated 1

NDRG1 belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

NDRG1's module in each cell type

Cell type	Module	Shares the module with
Endothelial	Glucocorticoid Response Endothelial cell development	APOLD1, DENND3, DPYSL2, JAM3, KLF11, KLF9, MFSD6, PHLPP1 +8 more	View in SCUBA
Enterocytes	PPARA/FXR fatty acid oxidation Lipid metabolism	ALDH18A1, ANO10, CPT1A, DGKD, FAT1, FMO5, NR1H4, PPARA +4 more	View in SCUBA
Gamma-delta T cells	Cytotoxic Effector Program cytotoxicity	APMAP, C16orf54, CST7, CTSW, EHD1, HLA-A, HLA-B, HLA-C +8 more
Innate lymphoid cells	Dissociation Stress Response Stress	C12orf57, CA2, CALM2, EHD1, EIF4A2, IER2, MEPCE, NUDT4 +9 more	View in SCUBA
Macrophages	Hypoxia Stress Response Stress	ACE, AMPD3, APP, ASPH, BCAT1, BEX3, BHLHE41, BNIP3 +34 more	View in SCUBA
Monocytes	Hypoxia Response Tissue adaptation	ANPEP, ELL2, GNA15, HIF1A, RUNX1, SDC4, SLC7A5, SPAG9 +2 more	View in SCUBA
Mucosal-associated invariant T cell	Retinoic Acid Response Tissue residence	C16orf54, CHRAC1, EHD1, MRPL10, PERP, RALGDS, RARA
Smooth muscle cells	Stromal Chemokine Secretion Inflammation	C7, CCL19, CCL2, CCL21, CH25H, CXCL12, CXCL2, LINC00924 +9 more	View in SCUBA

About the gene

Synonyms	CAP43, DRG1, NDR1, RTP, TDD5
Chromosome	8: 133237175-133302022
Predicted location	Intracellular, Membrane
Essential gene	No
Protein class	Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins

Function

Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53-mediated caspase activation and apoptosis. Has a role in cell trafficking, notably of the Schwann cell, and is necessary for the maintenance and development of the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle checkpoint. Regulates microtubule dynamics and maintains euploidy.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.