PPARA/FXR fatty acid oxidation
Gene co-expression module in Enterocytes
| Category | Lipid metabolism |
|---|---|
| Genes | 13 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 13 genes have a known function matching the annotation |
Why this annotation
Nuclear receptors PPARA and NR1H4 (FXR) plus CPT1A (a PPARA target) point to a fatty acid oxidation / bile-acid sensing program. FMO5 and NDRG1 are further metabolic targets in enterocytes. It is grouped with the neighboring enterocyte metabolic modules M24 and M30.
Genes
ALDH18A1, ANO10, CPT1A, DGKD, FAT1, FMO5, NDRG1, NR1H4, PPARA, SCAPER, SLC8A1, TFDP2, TNS3
Most correlated modules
- PGC1A/ERRG metabolic program · correlation 0.89
- Sterol Transfer · correlation 0.82
- Colonocyte Solute Transport · correlation 0.81
- Gluconeogenesis/fructose metabolism · correlation 0.81
- Brush-border nutrient uptake · correlation 0.80
- Mature colonocyte brush-border · correlation 0.78
- Carbohydrate Digestion/Detox · correlation 0.78
- Long-gene Nuclear Transcripts · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.