PPTC7 — Protein phosphatase targeting COQ7
PPTC7 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PPTC7's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Lymphatic endothelial | Stress Kinase Signaling Stress | ATP13A3, CLN8, CREBRF, CYLD, DYRK3, INO80D, IPO5, KLHL21 +6 more | View in SCUBA |
| Macrophages | ER-Golgi Trafficking Vesicular traficking | B4GALT5, CDC27, CLCN3, CUL1, GFPT1, HPS3, KCTD20, PTPN9 +5 more | View in SCUBA |
About the gene
| Synonyms | TA-PP2C |
|---|---|
| Chromosome | 12: 110533245-110583318 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins |
| Molecular function | Hydrolase, Protein phosphatase |
Function
Protein phosphatase that plays an essential role in mitochondrial metabolism and biogenesis. Positively regulates biosynthesis of the ubiquinone, coenzyme Q. Dephosphorylates the ubiquinone biosynthesis protein COQ7 which is likely to lead to its activation. Serves as a crucial sensor for mitophagy, though the underlying mechanism remains ambiguous (By similarity). May dephosphorylate BNIP3 and NIX and thereby directly regulates mitophagy receptor function and stability (By similarity). Alternatively, promotes SCF-FBXL4-dependent ubiquitination and degradation of BNIP3 and NIX independently of its catalytic activity to restrain mitophagy.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.