B4GALT5 — Beta-1,4-galactosyltransferase 5
B4GALT5 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
B4GALT5's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Lymphatic endothelial | NF-κB Innate Signaling Inflammation | AKAP13, BACH1, CHD2, CNST, DENND5A, HIVEP1, HIVEP2, IRAK2 +11 more | View in SCUBA |
| Macrophages | ER-Golgi Trafficking Vesicular traficking | CDC27, CLCN3, CUL1, GFPT1, HPS3, KCTD20, PPTC7, PTPN9 +5 more | View in SCUBA |
| Neutrophils | Granulopoiesis Program Developmental | ARHGAP24, ARID1B, CSGALNACT1, FLI1, IQGAP2, LYST, PDZD8, PHIP +5 more |
About the gene
| Synonyms | beta4GalT-V |
|---|---|
| Chromosome | 20: 49632945-49713878 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Glycosyltransferase, Transferase |
| Biological process | Lipid biosynthesis, Lipid metabolism, Sphingolipid metabolism |
Function
Catalyzes the synthesis of lactosylceramide (LacCer) via the transfer of galactose from UDP-galactose to glucosylceramide (GlcCer). LacCer is the starting point in the biosynthesis of all gangliosides (membrane-bound glycosphingolipids) which play pivotal roles in the CNS including neuronal maturation and axonal and myelin formation (By similarity). Plays a role in the glycosylation of BMPR1A and regulation of its protein stability (By similarity). Essential for extraembryonic development during early embryogenesis (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.