ER-Golgi Trafficking
Gene co-expression module in Macrophages
| Category | Vesicular traficking |
|---|---|
| Genes | 14 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 14 genes have a known function matching the annotation |
Why this annotation
Hub genes SEC24A and SEC24D are core COPII coat proteins mediating ER-to-Golgi vesicular transport. GFPT1 and B4GALT5 support glycosylation/hexosamine pathway activity. HPS3 links to lysosome-related organelle biogenesis. CLCN3 is an endosomal chloride channel. CUL1 and CDC27 contribute ubiquitin-proteasome regulation. The module is enriched in mono_mac and reflects secretory/glycosylation trafficking in monocyte-derived macrophages. All memberships are weak and coherence unknown, indicating a loosely co-regulated program.
Genes
B4GALT5, CDC27, CLCN3, CUL1, GFPT1, HPS3, KCTD20, PPTC7, PTPN9, QRICH1, SEC24A, SEC24D, TAF5L, TMEM184B
Most correlated modules
- ER-Golgi Trafficking · correlation 0.95
- NF-κB AP-1 Signaling · correlation 0.95
- RAB-mediated Trafficking · correlation 0.94
- RNA Processing Transport · correlation 0.94
- Transcriptional Regulation · correlation 0.92
- Sphingolipid Membrane Homeostasis · correlation 0.92
- Autophagy Vesicle Trafficking · correlation 0.91
- Transcriptional Repression · correlation 0.91
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.