CLCN3 — Chloride voltage-gated channel 3
CLCN3 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CLCN3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Ubiquitin Protein Quality Protein processing & ER | CHMP7, EDEM3, GART, GOPC, HERC4, KRIT1, LRIF1, PCMTD1 +13 more | |
| Lymphatic endothelial | Lymphatic Specification endothelial development | ARHGAP29, BOD1L1, CALD1, DECR1, GCC2, MINDY2, MPHOSPH8, MTUS1 +9 more | View in SCUBA |
| Macrophages | ER-Golgi Trafficking Vesicular traficking | B4GALT5, CDC27, CUL1, GFPT1, HPS3, KCTD20, PPTC7, PTPN9 +5 more | View in SCUBA |
| Mucosal-associated invariant T cell | Chromatin Epigenetic Regulation DNA/chromatin regulation | ACAP2, APBB1IP, ARHGAP25, ATM, CD247, CHD9, DDX17, FLI1 +14 more |
About the gene
| Synonyms | ClC-3, CLC3 |
|---|---|
| Chromosome | 4: 169612633-169723673 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins |
| Biological process | Antiport, Ion transport, Transport |
Function
Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons (By similarity). The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The presence of conserved gating glutamate residues is typical for family members that function as antiporters. Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.