Stress Kinase Signaling
Gene co-expression module in Lymphatic endothelial
| Category | Stress |
|---|---|
| Genes | 15 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 15 genes have a known function matching the annotation |
Why this annotation
Hub genes DYRK3 (stress granule kinase), MAPKAPK2 (p38 stress kinase effector), MAFG (oxidative/stress TF), CYLD (deubiquitinase regulating stress/NF-κB), CREBRF (CREB stress repressor), and CLN8 (ER stress-linked) collectively define a cellular stress signaling and protein homeostasis program. ATP13A3 links to polyamine-mediated stress tolerance. The module is uniformly expressed and coherent, consistent with a basal stress-response program in lymphatic endothelial cells.
Genes
ATP13A3, CLN8, CREBRF, CYLD, DYRK3, INO80D, IPO5, KLHL21, KMT2A, MAFG, MAPKAPK2, PPTC7, SERTAD2, TAF1D, ZBTB43
Most correlated modules
- Integrated Stress Response · correlation 0.86
- DNA Damage Apoptosis · correlation 0.83
- NF-κB Inflammatory Activation · correlation 0.83
- AhR mRNA Regulation · correlation 0.82
- NF-κB Autophagy Regulation · correlation 0.80
- NF-κB Negative Feedback · correlation 0.79
- NRF2 Oxidative Stress · correlation 0.79
- NF-κB Inflammatory Activation · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.