PRPF6 — Pre-mRNA processing factor 6
PRPF6 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PRPF6's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Chromatin TF Regulation DNA/chromatin regulation | ALDH9A1, ARMC1, ATIC, ERAP2, HDAC7, KAT8, LTN1, PHF14 +10 more |
About the gene
| Synonyms | ANT-1, bB152O15.1, C20orf14, hPrp6, Prp6, RP60, SNRNP102, TOM, U5-102K |
|---|---|
| Chromosome | 20: 63981132-64033100 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Disease related genes, Essential proteins, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
| Biological process | mRNA processing, mRNA splicing |
Function
Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.