Chromatin TF Regulation
Gene co-expression module in Gamma-delta T cells
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 19 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 19 genes have a known function matching the annotation |
Why this annotation
Hub genes include HDAC7 (class IIa HDAC, critical for T cell development and gene silencing), KAT8 (histone acetyltransferase), PHF14 (chromatin reader), and multiple zinc finger transcription factors (ZNF143, ZNF146, ZNF654, ZNF84). ERAP2 contributes antigen processing context. The module reflects a chromatin/transcriptional regulatory program broadly active in T cells. Moderate coherence consistent with combining chromatin regulation with transcription factor activity.
Genes
ALDH9A1, ARMC1, ATIC, ERAP2, HDAC7, KAT8, LTN1, PHF14, PRPF6, S100PBP, SLAMF6, SNX14, TRAP1, TRIP11, VARS1, ZNF143, ZNF146, ZNF654, ZNF84
Most correlated modules
- Rho GTPase Signaling · correlation 0.89
- mRNA Splicing Regulation · correlation 0.84
- Actin Cytoskeletal Regulation · correlation 0.82
- Ubiquitin Protein Quality · correlation 0.82
- Interferon Antiviral Response · correlation 0.81
- Immune Negative Regulation · correlation 0.81
- mRNA Splicing · correlation 0.78
- DNA Damage Repair · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.