LTN1 — Listerin E3 ubiquitin protein ligase 1
LTN1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
LTN1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Chromatin TF Regulation DNA/chromatin regulation | ALDH9A1, ARMC1, ATIC, ERAP2, HDAC7, KAT8, PHF14, PRPF6 +10 more | |
| Macrophages | RNA Processing Housekeeping Housekeeping | BAZ1A, BDP1, CCAR1, CCDC88A, CLIP1, CUL5, DHX36, DNM1L +32 more | View in SCUBA |
About the gene
| Synonyms | C21orf10, C21orf98, FLJ11053, KIAA0714, LISTERIN, RNF160, ZNF294 |
|---|---|
| Chromosome | 21: 28928144-28992956 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Transferase |
| Biological process | Ubl conjugation pathway |
Function
E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Within the RQC complex, LTN1 is recruited to stalled 60S ribosomal subunits by NEMF and mediates ubiquitination of stalled nascent chains. Ubiquitination leads to VCP/p97 recruitment for extraction and degradation of the incomplete translation product (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.