ERAP2 — Endoplasmic reticulum aminopeptidase 2
ERAP2 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ERAP2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Interferon response Anti-viral | ACBD5, AQP3, BTN2A1, BTN3A2, BTN3A3, CISH, EIF2AK2, GBP1 +23 more | View in SCUBA |
| Endothelial | IFN-gamma Antigen Processing Inflammation | GBP3, IFI35, OAS1, PSMB8, PSMB9, PSME1, RNF213, SAMD9L +3 more | View in SCUBA |
| Gamma-delta T cells | Chromatin TF Regulation DNA/chromatin regulation | ALDH9A1, ARMC1, ATIC, HDAC7, KAT8, LTN1, PHF14, PRPF6 +10 more |
About the gene
| Synonyms | L-RAP, LRAP |
|---|---|
| Chromosome | 5: 96875986-96919703 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins, Predicted secreted proteins |
| Molecular function | Aminopeptidase, Hydrolase, Metalloprotease, Protease |
| Biological process | Adaptive immunity, Immunity |
Function
Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg and Lys.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.