HDAC7 — Histone deacetylase 7
HDAC7 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HDAC7's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | T-cell activation TCR/AP1/NFKb pathway | C16orf87, CAMK1, CBLB, CD4, CD7, CDK6, CIAO1, COPB2 +7 more | View in SCUBA |
| Endothelial | Venous Endothelial Identity Endothelial cell development | ABI3, CCDC85B, DOCK4, EHD4, EVA1B, EXOC3L2, ITGA6, MCF2L +8 more | View in SCUBA |
| Gamma-delta T cells | Chromatin TF Regulation DNA/chromatin regulation | ALDH9A1, ARMC1, ATIC, ERAP2, KAT8, LTN1, PHF14, PRPF6 +10 more | |
| Mucosal-associated invariant T cell | Chromatin Complex Regulation DNA/chromatin regulation | APEH, CAPZB, CCND2, CFH, CHTF8, ESYT1, GDI2, HACD4 +9 more |
About the gene
| Synonyms | DKFZP586J0917, HDAC7A |
|---|---|
| Chromosome | 12: 47782722-47833132 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Chromatin regulator, Hydrolase, Repressor |
| Biological process | Transcription, Transcription regulation |
Function
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (By similarity). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C (By similarity). During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene. Positively regulates the transcriptional repressor activity of FOXP3. Serves as a corepressor of RARA, causing its deacetylation and inhibition of RARE DNA element binding. In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response. Also acetylates non-histone proteins, such as ALKBH5.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.