PHF14 — PHD finger protein 14
PHF14 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PHF14's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Chromatin TF Regulation DNA/chromatin regulation | ALDH9A1, ARMC1, ATIC, ERAP2, HDAC7, KAT8, LTN1, PRPF6 +10 more | |
| Innate lymphoid cells | NK Cytotoxic Regulation Cytotoxicity | ARHGAP30, BIN2, CAPN12, CHD9, CLK1, CTSC, CYB5B, DDX27 +29 more | View in SCUBA |
| Lymphatic endothelial | Endosomal Vesicle Trafficking Housekeeping | ADAM10, APC, APP, ATP9A, GLG1, MTR, NCOA3, PCNX4 +5 more | View in SCUBA |
| Mucosal-associated invariant T cell | Chemokine Receptor Migration migration & adhesion | CCR1, CCR2, CCR5, CD47, FAM78A, KRIT1, LUC7L3, MTG1 +6 more | |
| Smooth muscle cells | Synthetic Matrix Phenotype ECM remodeling | APOE, CFD, GAS6, GJA1, MAP1LC3A, MXRA5, PLAU, POSTN +1 more | View in SCUBA |
About the gene
| Synonyms | KIAA0783 |
|---|---|
| Chromosome | 7: 10973336-11169623 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
Histone-binding protein. Binds preferentially to unmodified histone H3 but can also bind to a lesser extent to histone H3 trimethylated at 'Lys-9' (H3K9me3) as well as to histone H3 monomethylated at 'Lys-27' (H3K27ac) and trimethylated at 'Lys-27' (H3K27me3) (By similarity). Represses PDGFRA expression, thus playing a role in regulation of mesenchymal cell proliferation (By similarity). Suppresses the expression of CDKN1A/p21 by reducing the level of trimethylation of histone H3 'Lys-4', leading to enhanced proliferation of germinal center B cells (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.