PTS — 6-pyruvoyltetrahydropterin synthase
PTS belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PTS's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Inflammatory Fibroblast Activation Inflammatory | ADAM9, CALU, CLMP, CNN3, GLIPR1, ITGAV, MCRIP1, NAP1L1 +5 more | View in SCUBA |
About the gene
| Synonyms | PTPS |
|---|---|
| Chromosome | 11: 112226367-112269955 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Lyase |
| Biological process | Tetrahydrobiopterin biosynthesis |
Function
Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.