DYNLT3 — Dynein light chain Tctex-type 3
DYNLT3 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DYNLT3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Resting memory T cell Immune regulation | ANXA1, CD300A, CDC14A, CYB561, DHRS3, IL7R, MYADM, NECTIN3 +5 more | View in SCUBA |
| Fibroblasts | Rho-ROCK Contractility Cytoskeletal | ANXA6, ATP2B4, CBX6, CSDE1, GNG12, ITM2C, PPP1CB, ROCK1 +1 more | View in SCUBA |
| Gamma-delta T cells | AHR/NF-κB Survival Immune regulation | ABCC1, AHR, ANKRD37, AREG, BAIAP2, BCL2L11, BEND4, BIRC3 +24 more | |
| Innate lymphoid cells | IFN-driven ILC1 Activation Inflammation | AFF3, AGPAT5, AKIRIN2, APMAP, ARF6, ARHGEF1, DNAJC1, ELOVL5 +21 more | View in SCUBA |
About the gene
| Synonyms | TCTE1L, TCTEX1L |
|---|---|
| Chromosome | X: 37836757-37847571 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Motor protein |
| Biological process | Cell cycle, Cell division, Mitosis, Transport |
Function
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Probably binds BUB3 as part of transport cargo. Required for the efficient progression through mitosis (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.