MCRIP1 — MAPK regulated corepressor interacting protein 1
MCRIP1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MCRIP1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Inflammatory Fibroblast Activation Inflammatory | ADAM9, CALU, CLMP, CNN3, GLIPR1, ITGAV, NAP1L1, PRNP +5 more | View in SCUBA |
| Gamma-delta T cells | Chromatin Epigenetic Regulation DNA/chromatin regulation | CASP8AP2, CNPPD1, CUL4A, CYBC1, EPRS1, FAM8A1, GTF2H3, IL17RA +15 more | |
| Innate lymphoid cells | mTOR Metabolic Stress Stress | ADPGK, AKR1A1, ATP5IF1, BAX, CPNE1, GLO1, GSTO1, HNRNPR +9 more | View in SCUBA |
| Macrophages | RNA Processing Housekeeping Housekeeping | CISD3, CNIH4, DDX52, DPH3, EXOSC6, FABP5, GTF2E2, IKBKE +20 more | View in SCUBA |
| Smooth muscle cells | ATP Synthase Complex Mitochondrial & OxPhos | ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1E, ATP5MC1, ATP5MC2, ATP5MC3, ATP5ME +8 more | View in SCUBA |
About the gene
| Synonyms | FAM195B, GRAN2, MCRIP |
|---|---|
| Chromosome | 17: 81822361-81833302 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
The phosphorylation status of MCRIP1 functions as a molecular switch to regulate epithelial-mesenchymal transition. Unphosphorylated MCRIP1 binds to and inhibits the transcriptional corepressor CTBP(s). When phosphorylated by MAPK/ERK, MCRIP1 releases CTBP(s) resulting in transcriptional silencing of the E-cadherin gene and induction of epithelial-mesenchymal transition
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.