CNN3 — Calponin 3
CNN3 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CNN3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Lipid Droplet Hypoxia Stress | BNIP3, CEMIP2, FCGRT, FGD6, PLIN2, SNTB2, TSPAN4 | View in SCUBA |
| Fibroblasts | Inflammatory Fibroblast Activation Inflammatory | ADAM9, CALU, CLMP, GLIPR1, ITGAV, MCRIP1, NAP1L1, PRNP +5 more | View in SCUBA |
| Glial cells | ER-Mitochondria Housekeeping Mitochondrial & OxPhos | COX6C, HMGN3, LDHB, NDUFB5, NDUFS8, PDIA3, TMBIM4, TMBIM6 +2 more | View in SCUBA |
| Pericytes | Focal Adhesion Cytoskeleton Cytoskeletal | ARPC5, CAVIN3, MAP1B, MYL6, PDLIM2, TGFB1I1, TLN1, TPM4 | View in SCUBA |
| Smooth muscle cells | Activated Myofibroblast Activation | EPHX1, IFI16, IGFBP4, LAPTM4B, NNMT, SERPING1, SSR4, SULF1 +3 more | View in SCUBA |
About the gene
| Chromosome | 1: 94896949-94927223 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
| Molecular function | Actin-binding, Calmodulin-binding |
Function
Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.