Inflammatory Fibroblast Activation
Gene co-expression module in Fibroblasts
| Category | Inflammatory |
|---|---|
| Genes | 14 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 14 genes have a known function matching the annotation |
Why this annotation
Top hub genes include TPM4 (tropomyosin 4, actin filament stabilization), ITGAV (integrin alpha-V, RGD-binding, involved in TGF-beta activation and ECM adhesion), CNN3 (calponin 3, actin-binding), ADAM9 (metalloprotease-disintegrin, ECM remodeling and integrin shedding), GLIPR1 (GLI pathogenesis-related, inflammation/apoptosis), CLMP (CXADR-like membrane protein, cell junction), TNFRSF1A (TNF receptor 1, inflammatory signaling), and CALU (calumenin, ER calcium-binding). The module combines cytoskeletal (TPM4, CNN3), integrin/adhesion (ITGAV, CLMP), and inflammatory receptor (TNFRSF1A, GLIPR1) components. The strong upregulation in CD inflammation and reversal in CD remission suggests an inflammatory fibroblast activation state. ITGAV is a known driver of TGF-beta activation in intestinal fibrosis. Neighbor context: M5 (actin-integrin) and M111 (ECM production) support a fibroblast activation neighborhood; M71 bridges cytoskeletal remodeling with inflammatory signaling.
Genes
ADAM9, CALU, CLMP, CNN3, GLIPR1, ITGAV, MCRIP1, NAP1L1, PRNP, PTS, RBMS1, RCN1, TNFRSF1A, TPM4
Most correlated modules
- ER Protein Processing · correlation 0.91
- Rho GTPase Cytoskeletal · correlation 0.90
- ER Protein Folding · correlation 0.90
- Cullin-RING Ubiquitin Ligase · correlation 0.89
- Collagen ECM Production · correlation 0.89
- Actin-Integrin Adhesion · correlation 0.88
- Actin Cytoskeleton · correlation 0.88
- Proteasome Assembly · correlation 0.87
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.