Hypoxic Oxidative Stress
Gene co-expression module in Colonocytes
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 25 genes have a known function matching the annotation |
Why this annotation
Hub genes SERPINB1 (serine protease inhibitor, neutrophil elastase inhibitor), LDHA (lactate dehydrogenase A, anaerobic glycolysis/hypoxia marker), ANXA2 (annexin A2, membrane repair, plasminogen receptor), GLRX (glutaredoxin, thiol redox), PRDX1 (peroxiredoxin 1, H2O2 scavenging), S100A16 (calcium-binding, inflammation), HEBP2 (heme-binding protein 2, oxidative stress). RAB10 and RAB5IF contribute vesicle trafficking. NDFIP1 links to ubiquitin/Nedd4. The combination of LDHA (glycolytic shift), GLRX+PRDX1 (antioxidant defense), SERPINB1 (protease inhibition), and ANXA2 (membrane repair) in inf_colono-enriched cells is characteristic of a hypoxia-driven oxidative stress response in inflamed colonocytes. Neighbor M100 shares the metabolic reprogramming theme (ME1, NAMPT), supporting a coordinated metabolic stress response.
Genes
Most correlated modules
- ER-Golgi Trafficking · correlation 0.94
- Arp2/3 Actin Branching · correlation 0.94
- Integrin Adhesion Signaling · correlation 0.90
- mTOR Lysosomal Sensing · correlation 0.83
- Ubiquitin Signaling Response · correlation 0.83
- Unfolded Protein Response · correlation 0.82
- Chromatin Regulatory Response · correlation 0.82
- ER Stress & Trafficking · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.