PVRIG — PVR related immunoglobulin domain containing
PVRIG belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PVRIG's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Coinhibitory Checkpoint Exhaustion | BTN3A2, CDC25B, CDC42EP3, DDTL, FAM117A, FLOT2, GBP5, GGPS1 +12 more | |
| Mucosal-associated invariant T cell | Cytoskeletal Remodeling Migration migration & adhesion | ADAM8, BIN2, C11orf21, CAPN1, CAPN2, CD52, CDC25B, CNN2 +14 more |
About the gene
| Synonyms | C7orf15, CD112R, MGC2463 |
|---|---|
| Chromosome | 7: 100218241-100221490 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins |
| Molecular function | Receptor |
Function
Cell surface receptor for NECTIN2. May act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals. Following interaction with NECTIN2, inhibits T-cell proliferation. Competes with CD226 for NECTIN2-binding
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.