Coinhibitory Checkpoint
Gene co-expression module in Gamma-delta T cells
| Category | Exhaustion |
|---|---|
| Genes | 21 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 21 genes have a known function matching the annotation |
Why this annotation
Hub genes PVRIG (coinhibitory receptor), VSIR/VISTA (checkpoint receptor), and BTN3A2 (butyrophilin ligand for Vγ9Vδ2 TCR) define an immune checkpoint/coinhibitory program. Supporting genes GRAP2 (T cell adaptor), GBP5 (IFN-stimulated), CDC25B (cell cycle regulator in T cells), and FLOT2 (lipid raft signaling) are consistent with an exhaustion/checkpoint state. PVRIG and VSIR are both well-characterized coinhibitory receptors on T cells. BTN3A2 is specifically relevant to γδ T cell biology. This module captures coinhibitory receptor expression characteristic of the exhausted or tolerant γδ T cell state.
Genes
BTN3A2, CDC25B, CDC42EP3, DDTL, FAM117A, FLOT2, GBP5, GGPS1, GRAP2, HYPK, KCNAB2, LBH, MRPL53, PVRIG, RAB29, RBM34, RFLNA, RHBDF2, UTS2, VSIR, ZNF276
Most correlated modules
- TCR Proximal Signaling · correlation 0.94
- Immune Synapse Cytoskeleton · correlation 0.93
- Effector Cell Migration · correlation 0.92
- Lymphocyte Tissue Egress · correlation 0.91
- γδ T Cell Identity · correlation 0.85
- Lymphocyte Homeostatic Regulation · correlation 0.84
- TCR-Cytokine Signaling · correlation 0.84
- T-bet Effector Differentiation · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.