Cytoskeletal Remodeling Migration
Gene co-expression module in Mucosal-associated invariant T cell
| Category | migration & adhesion |
|---|---|
| Genes | 23 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 12 of 23 genes have a known function matching the annotation |
Why this annotation
Core coherence module dominated by cytoskeletal remodeling genes: MYO1G (non-muscle myosin), CAPN2 (calpain-2 protease for cytoskeletal remodeling), CNN2 (calponin actin-binding), PXN (paxillin focal adhesion scaffold), BIN2 (membrane curvature/endocytosis), ADAM8 (metalloprotease for migration). SYTL1 (synaptotagmin-like) links to degranulation vesicle trafficking. ITGB7 mediates gut-homing integrin signaling. FLOT2 (flotillin-2) organizes membrane rafts for signaling. CDC25B controls G2/M but in effector T cells also regulates cytoskeletal dynamics. Overall, this is a cytoskeletal remodeling and migratory effector program.
Genes
ADAM8, BIN2, C11orf21, CAPN1, CAPN2, CD52, CDC25B, CNN2, CYB561, DDTL, FLOT2, ITGB7, MATK, MYO1G, NSG1, PLEKHG3, PVRIG, PXN, RAB37, RARG, SEC31A, SH3BP1, SYTL1
Most correlated modules
- Mature Effector MAIT · correlation 0.88
- T cell Surface Signaling · correlation 0.87
- TCR Signaling Identity · correlation 0.84
- Chromatin Complex Regulation · correlation 0.80
- Cytotoxic Lymphocyte Program · correlation 0.80
- PI3K-Calcineurin Signaling · correlation 0.76
- IL-12 Cytotoxic Effector · correlation 0.73
- Chromatin Maintenance State · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.