RFX3 — Regulatory factor X3
RFX3 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RFX3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Lymphatic endothelial | Rho/Ras GTPase Regulation Cytoskeletal | ASAP1, CADPS2, CDK17, ERC1, ETV6, KIF13A, LDLRAD4, LMBR1 +4 more | View in SCUBA |
| Macrophages | Endosomal Rab Trafficking Vesicular traficking | ABL1, ANKS1A, ARB2A, CAMK1D, CPEB3, DENND4C, DISC1, FBXL17 +15 more | View in SCUBA |
About the gene
| Chromosome | 9: 3218297-3526004 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Transcription factors |
| Molecular function | Developmental protein, DNA-binding, Repressor |
| Biological process | Differentiation, Transcription, Transcription regulation |
Function
Transcription factor required for ciliogenesis and islet cell differentiation during endocrine pancreas development. Essential for the differentiation of nodal monocilia and left-right asymmetry specification during embryogenesis. Required for the biogenesis of motile cilia by governing growth and beating efficiency of motile cells. Also required for ciliated ependymal cell differentiation. Regulates the expression of genes involved in ciliary assembly (DYNC2LI1, FOXJ1 and BBS4) and genes involved in ciliary motility (DNAH11, DNAH9 and DNAH5) (By similarity). Together with RFX6, participates in the differentiation of 4 of the 5 islet cell types during endocrine pancreas development, with the exception of pancreatic PP (polypeptide-producing) cells. Regulates transcription by forming a heterodimer with another RFX protein and binding to the X-box in the promoter of target genes. Represses transcription of MAP1A in non-neuronal cells but not in neuronal cells.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.