LDLRAD4 — Low density lipoprotein receptor class A domain containing 4
LDLRAD4 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
LDLRAD4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Activation/Migration BCR/AP1/NFKb pathway | AHNAK, DUSP10, DUSP8, GGA1, GPR183, GPR65, IDS, KLF6 +11 more | View in SCUBA |
| Enterocytes | Long-gene nuclear transcripts Technical artifact | ARL15, BLNK, CERS6, EXT1, FHIT, FUT8, KANK1, LRBA +6 more | View in SCUBA |
| Gamma-delta T cells | Hypoxia Tissue Adaptation Tissue residence | ABCB1, ADAMTS17, ANKRD28, CCRL2, EPAS1, FAM3C, KLHL6, PHTF1 +10 more | |
| Innate lymphoid cells | NK ILC Tissue Homing Homing & TEM | ADGRE5, AKAP13, AREG, ARL4C, ATP1B3, B3GNT7, BTG1, CCDC107 +25 more | View in SCUBA |
| Lymphatic endothelial | Rho/Ras GTPase Regulation Cytoskeletal | ASAP1, CADPS2, CDK17, ERC1, ETV6, KIF13A, LMBR1, PLEKHG1 +4 more | View in SCUBA |
| Monocytes | Tissue-destructive Macrophage Lysosomal & pahgocytosis | ACP5, ANKH, BCAT1, ENG, FABP5, ID3, IL10, KIFC3 +7 more | View in SCUBA |
| Natural Killer cells | NK Tissue Residency Gut residency | ENTPD1, GEM, GPR171, ITGA1, KLHL23, PHYKPL, RCAN3 | View in SCUBA |
About the gene
| Synonyms | C18orf1 |
|---|---|
| Chromosome | 18: 13217498-13652755 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Signal transduction inhibitor |
Function
Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.