Rho/Ras GTPase Regulation
Gene co-expression module in Lymphatic endothelial
| Category | Cytoskeletal |
|---|---|
| Genes | 13 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 13 genes have a known function matching the annotation |
Why this annotation
STARD13 (DLC2/ARHGAP37, RhoGAP), RASAL2 (RasGAP), ASAP1 (ArfGAP at focal adhesions), PLEKHG1 (RhoGEF), and CDK17 (PCTAIRE2 kinase, cytoskeletal) define a Rho/Ras GTPase regulatory module. ERC1 (ELKS) scaffolds active zones and is linked to Arf/Rab GTPase signaling. KIF13A is a kinesin involved in vesicle transport. CADPS2 (calcium-dependent secretion activator) and TANC1 (postsynaptic scaffold) are peripheral. The convergence of multiple GTPase regulators (GAPs and GEFs) in LECs suggests fine-tuning of cytoskeletal polarity, consistent with the broader neighborhood theme.
Genes
ASAP1, CADPS2, CDK17, ERC1, ETV6, KIF13A, LDLRAD4, LMBR1, PLEKHG1, RASAL2, RFX3, STARD13, TANC1
Most correlated modules
- Focal Adhesion Migration · correlation 0.97
- Actin-based Migration · correlation 0.97
- Polarized Vesicle Trafficking · correlation 0.97
- Hippo-Adhesion Signaling · correlation 0.96
- Chromatin Remodeling · correlation 0.95
- Cilia Centrosome Program · correlation 0.95
- Inflammatory cAMP Response · correlation 0.93
- Lipid Metabolic Regulation · correlation 0.93
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.