Endosomal Rab Trafficking
Gene co-expression module in Macrophages
| Category | Vesicular traficking |
|---|---|
| Genes | 24 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 24 genes have a known function matching the annotation |
Why this annotation
RIC1 (Rab6 GEF), DENND4C (DENN-domain Rab GEF), TBC1D5 (Rab GAP linking endosomes to autophagy), ANKS1A (endosomal EGFR trafficking adaptor), and MGAT5 (Golgi N-glycosyltransferase) collectively point to endosomal/Golgi membrane trafficking and glycosylation. SUMF1 (ER sulfatase modifier) adds ER processing. PLCL2, CAMK1D, and ABL1 contribute signaling. TCF12 and ZNF609 are transcription factors. The module is weakly coherent with uniform expression; the most consistent theme across hub genes is endosomal Rab-mediated trafficking.
Genes
ABL1, ANKS1A, ARB2A, CAMK1D, CPEB3, DENND4C, DISC1, FBXL17, FTO, GAB1, HEATR5B, ITSN1, MGAT5, PLCL2, RABGAP1L, RFX3, RIC1, SLC2A13, SUMF1, TBC1D5, TCF12, TMCC1, XPR1, ZNF609
Most correlated modules
- Golgi Vesicle Trafficking · correlation 0.98
- Transcriptional Kinase Regulation · correlation 0.97
- Ubiquitin Proteasome Regulation · correlation 0.97
- Rho GTPase Signaling · correlation 0.96
- Transcriptional Regulation · correlation 0.96
- Macrophage Migration · correlation 0.95
- MITF Lysosomal Program · correlation 0.94
- DNA Damage Response · correlation 0.93
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.