ERC1 — ELKS/RAB6-interacting/CAST family member 1
ERC1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ERC1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Cytoskeletal Scaffolding Cytoskeletal | ADD1, AGPAT1, ANO6, ARL6IP5, CDC42BPA, CHURC1, DOCK1, MAP4 +6 more | View in SCUBA |
| Gamma-delta T cells | JNK/MAPK Stress Signaling Stress | ABTB3, BICRAL, COP1, DICER1, ELMO1, FBXO11, FCHSD2, FGFR1 +19 more | |
| Lymphatic endothelial | Rho/Ras GTPase Regulation Cytoskeletal | ASAP1, CADPS2, CDK17, ETV6, KIF13A, LDLRAD4, LMBR1, PLEKHG1 +4 more | View in SCUBA |
| Macrophages | Rho GTPase Signaling Cytoskeletal | ABCC1, ABR, ANKRD17, ARFGEF2, ARHGAP10, ARID2, ATAD2B, ATP9B +44 more | View in SCUBA |
About the gene
| Synonyms | CAST2, ELKS, KIAA1081, MGC12974, RAB6IP2 |
|---|---|
| Chromosome | 12: 990509-1495933 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Predicted intracellular proteins |
| Biological process | Protein transport, Transport |
Function
Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.