RHBDF2 — Rhomboid 5 homolog 2
RHBDF2 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RHBDF2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Th17 lineage Th17 fate | ADA, ARHGEF3, CD226, CD52, DENND3, EVL, IDH2, IL17RE +13 more | View in SCUBA |
| Gamma-delta T cells | Coinhibitory Checkpoint Exhaustion | BTN3A2, CDC25B, CDC42EP3, DDTL, FAM117A, FLOT2, GBP5, GGPS1 +12 more | |
| Macrophages | NF-κB AP-1 Signaling Inflammatory | ABL2, AGAP3, ARL8B, ATP1B3, ATP6V1H, B4GALT1, C5AR2, CDKN1A +21 more | View in SCUBA |
About the gene
| Synonyms | FLJ22341, iRhom2, RHBDL5, RHBDL6, TOC, TOCG |
|---|---|
| Chromosome | 17: 76470891-76501790 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Growth factor binding |
| Biological process | Protein transport, Transport |
Function
Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.