NF-κB AP-1 Signaling
Gene co-expression module in Macrophages
| Category | Inflammatory |
|---|---|
| Genes | 30 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 13 of 30 genes have a known function matching the annotation |
Why this annotation
Notable hub genes: WTAP (m6A RNA methylation writer complex), FOSL2 (AP-1 transcription factor, macrophage activation), MDM2 (E3 ubiquitin ligase, p53 regulator), RHBDF2 (iRhom2 — essential regulator of ADAM17/TACE for TNF-α ectodomain shedding, a key macrophage inflammatory mediator), TANK (TRAF family member-associated NF-κB activator, connects to TBK1/IKK signaling), GNA13 (G-protein alpha 13, inflammatory signaling), ITPR1 (IP3 receptor, calcium signaling), ARL8B (lysosomal positioning Rab-like GTPase), ATP6V1H (V-ATPase subunit, lysosomal acidification), FNIP2 (FLCN-interacting protein, mTOR/AMPK), SAMSN1 (SH3 domain immune signaling adaptor). RHBDF2, TANK, FOSL2, and GNA13 collectively point toward NF-κB/AP-1 inflammatory signaling. The lysosomal components (ATP6V1H, ARL8B) and mTOR regulator (FNIP2) suggest integration with metabolic/lysosomal signaling. This module likely reflects NF-κB/AP-1 inflammatory signaling in monocyte-derived macrophages.
Genes
ABL2, AGAP3, ARL8B, ATP1B3, ATP6V1H, B4GALT1, C5AR2, CDKN1A, CERT1, CHSY1, CREM, EZR, FNIP2, FOSL2, GNA13, ITPR1, KBTBD2, MDM2, PTPN1, RHBDF2, RNF145, SAMSN1, SH3BP5, ST3GAL1, STX3, TANK, TXNDC11, WTAP, ZMIZ1, ZNF267
Most correlated modules
- Transcriptional Regulation · correlation 0.96
- Microtubule Organization · correlation 0.96
- Autophagy Vesicle Trafficking · correlation 0.95
- RAB-mediated Trafficking · correlation 0.95
- ER-Golgi Trafficking · correlation 0.95
- Transcriptional Repression · correlation 0.94
- Transcriptional Regulation · correlation 0.94
- Ubiquitin-Proteasome Regulation · correlation 0.93
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.