ABL2 — ABL proto-oncogene 2, non-receptor tyrosine kinase
ABL2 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ABL2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Chronic Inflammatory Activation Inflammation | ADAMTS9, DDX21, EMP1, FOSL2, HRH1, KRT10, LMNA, PNP +2 more | View in SCUBA |
| Fibroblasts | Hypoxia Metabolic Stress Stress | DYRK3, EMP1, ERRFI1, HMOX1, NFATC1, PFKFB3, PIM1, SERPINE1 +3 more | View in SCUBA |
| Glial cells | COX-2/NF-κB Inflammation Inflammation | ARID5A, BCL3, EMP1, LMNA, PDLIM3, PHLDA1, PTGS2 | View in SCUBA |
| Macrophages | NF-κB AP-1 Signaling Inflammatory | AGAP3, ARL8B, ATP1B3, ATP6V1H, B4GALT1, C5AR2, CDKN1A, CERT1 +21 more | View in SCUBA |
| Monocytes | NF-κB Counter-regulation Inflammatory | C15orf48, CD274, GPR84, IL1RN, RHOH, TNFAIP8, TNIP3 | View in SCUBA |
| Pericytes | NF-κB Inflammatory Response Inflammatory | ADAMTS9, ARL4A, BCL3, BHLHE40, FOSL2, ICAM1, KLF10, PIM3 +3 more | View in SCUBA |
About the gene
| Synonyms | ABLL, ARG |
|---|---|
| Chromosome | 1: 179099330-179229684 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Enzymes, Predicted intracellular proteins, RAS pathway related proteins |
| Molecular function | Kinase, Transferase, Tyrosine-protein kinase |
| Biological process | Cell adhesion |
Function
Non-receptor tyrosine-protein kinase that plays an ABL1- overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin- bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 also acts as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.