C5AR2 — Complement C5a receptor 2
C5AR2 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
C5AR2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Inflammatory Fibroblast Activation Inflammatory | ATP2A2, BAMBI, CRISPLD2, CSNK1E, CTNNB1, DLC1, ETS2, F2RL3 +11 more | View in SCUBA |
| Macrophages | NF-κB AP-1 Signaling Inflammatory | ABL2, AGAP3, ARL8B, ATP1B3, ATP6V1H, B4GALT1, CDKN1A, CERT1 +21 more | View in SCUBA |
| Monocytes | Complement Receptor Activation Lysosomal & pahgocytosis | AVPI1, C5AR1, CLEC7A, CSF2RA, MAT2A, METRNL, PTPRE, RAB20 +1 more | View in SCUBA |
About the gene
| Synonyms | C5L2, GPR77 |
|---|---|
| Chromosome | 19: 47332175-47347329 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | G-protein coupled receptors, Predicted membrane proteins |
| Molecular function | G-protein coupled receptor, Receptor, Transducer |
Function
Receptor for the chemotactic and inflammatory C3a, C4a and C5a anaphylatoxin peptides and also for their dearginated forms ASP/C3adesArg, C4adesArg and C5adesArg respectively. Couples weakly to G(i)-mediated signaling pathways.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.