RPS6KA2 — Ribosomal protein S6 kinase A2
RPS6KA2 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RPS6KA2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | WNT4+ Stromal Fibroblast Developmental | CARD16, CASP1, FBLIM1, FHL2, GRK5, IQGAP2, OTULINL, PIEZO2 +7 more | View in SCUBA |
| Pericytes | BMP Receptor Signaling Developmental | BMPR2, CRK, LRRC8C, PLEKHG1, PTPRN2, RBMS2, SNAP23, TMEM181 +1 more | View in SCUBA |
About the gene
| Synonyms | HU-2, RSK3 |
|---|---|
| Chromosome | 6: 166409364-166906451 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Function
Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.