BMP Receptor Signaling
Gene co-expression module in Pericytes
| Category | Developmental |
|---|---|
| Genes | 10 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 10 genes have a known function matching the annotation |
Why this annotation
BMPR2 is the dominant hub gene — it encodes BMP receptor type 2, a critical receptor in pericyte and vascular smooth muscle biology that mediates BMP signaling for vascular homeostasis and remodeling. This module shows significant upregulation in UC inflammation (delta_inflammation_UC = 0.430, sig.), consistent with inflammatory vascular remodeling. SNAP23 (SNARE vesicle fusion), CRK (adaptor for growth factor/BMP downstream signaling), RPS6KA2 (RSK3, downstream of MAPK/BMP), and PLEKHG1 (Rho GEF, cytoskeletal remodeling downstream of BMP) support BMP receptor-mediated signaling. PTPRN2 and LRRC8C may modulate receptor activity. Neighbor modules M69 (ENG/TAZ) and M66 (SKIL/SMURF2) also involve TGF-β superfamily signaling, reinforcing this assignment.
Genes
BMPR2, CRK, LRRC8C, PLEKHG1, PTPRN2, RBMS2, RPS6KA2, SNAP23, TMEM181, ZDHHC20
Most correlated modules
- TGF-beta Negative Feedback · correlation 0.97
- YAP/TAZ Mechanosensing · correlation 0.97
- Vascular Junction Adhesion · correlation 0.97
- G1 Cell Cycle Entry · correlation 0.96
- RAS Cytoskeletal Signaling · correlation 0.95
- Actin-ERM Migration · correlation 0.95
- Golgi Vesicular Trafficking · correlation 0.94
- Angiogenic Receptor Signaling · correlation 0.93
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.