LRRC8C — Leucine rich repeat containing 8 VRAC subunit C
LRRC8C belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
LRRC8C's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Actomyosin Contractility Cytoskeletal | BCAP29, CAPN2, GNB2, INPP5A, ITPRIPL2, LGALS1, MPRIP, NID1 +2 more | View in SCUBA |
| Gamma-delta T cells | JNK/MAPK Stress Signaling Stress | ABTB3, BICRAL, COP1, DICER1, ELMO1, ERC1, FBXO11, FCHSD2 +19 more | |
| Macrophages | Mixed Regulatory Signaling Housekeeping | ADAP2, AKAP11, ARHGAP17, ARHGAP27, BLTP2, BLTP3A, C2CD2L, COG2 +30 more | View in SCUBA |
| Pericytes | BMP Receptor Signaling Developmental | BMPR2, CRK, PLEKHG1, PTPRN2, RBMS2, RPS6KA2, SNAP23, TMEM181 +1 more | View in SCUBA |
About the gene
| Synonyms | AD158 |
|---|---|
| Chromosome | 1: 89633072-89769903 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins, Transporters |
| Molecular function | Ion channel |
| Biological process | Ion transport, Transport |
Function
Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. Plays a redundant role in the efflux of amino acids, such as aspartate and glutamate, in response to osmotic stress. The VRAC channel also mediates transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.