WNT4+ Stromal Fibroblast
Gene co-expression module in Fibroblasts
| Category | Developmental |
|---|---|
| Genes | 16 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 16 genes have a known function matching the annotation |
Why this annotation
Hub genes include WNT4 (Wnt ligand expressed by stromal fibroblasts), FBLIM1 (focal adhesion LIM protein), PTGER2 (prostaglandin E2 receptor, inflammatory signaling), GRK5 (GPCR kinase), CASP1 (caspase-1, inflammasome effector), CARD16 (caspase recruitment domain, inflammasome), UNC5C (netrin receptor), FHL2 (LIM domain scaffold), IQGAP2 (cytoskeletal scaffold), PROCR (protein C receptor, endothelial/stromal), and TAC3 (tachykinin neuropeptide). WNT4 marks a Wnt-secreting fibroblast subpopulation. CASP1 and CARD16 suggest inflammasome activity. The mild but significant inflammation downregulation in both UC and CD is consistent with a Wnt-active stromal niche cell.
Genes
CARD16, CASP1, FBLIM1, FHL2, GRK5, IQGAP2, OTULINL, PIEZO2, PROCR, PSD3, PTGER2, RPS6KA2, RRBP1, TAC3, UNC5C, WNT4
Most correlated modules
- Pericyte-like Fibroblast · correlation 0.71
- Wnt-BMP Fibroblast · correlation 0.70
- CYGB+ Quiescent Fibroblast · correlation 0.64
- BMP-ECM Fibroblast · correlation 0.62
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.