FBLIM1 — Filamin binding LIM protein 1
FBLIM1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FBLIM1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | WNT4+ Stromal Fibroblast Developmental | CARD16, CASP1, FHL2, GRK5, IQGAP2, OTULINL, PIEZO2, PROCR +7 more | View in SCUBA |
| Pericytes | Pericyte Identity Signaling Developmental | ADCY3, CCDC102B, NOTCH3, OLFML2B, PDGFRB, PEAK1, PLXDC1 | View in SCUBA |
| Smooth muscle cells | ER Chaperone/UPR Protein processing & ER | CALR, CRISPLD2, HIF1A, HSP90B1, HSPA5, IL6ST, OSMR, PCOLCE +3 more | View in SCUBA |
About the gene
| Synonyms | CAL, FBLP-1, migfilin |
|---|---|
| Chromosome | 1: 15756607-15786594 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
| Biological process | Cell adhesion, Cell shape |
Function
Serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. Is implicated in cell shape modulation (spreading) and motility. May participate in the regulation of filamin-mediated cross-linking and stabilization of actin filaments. May also regulate the assembly of filamin-containing signaling complexes that control actin assembly. Promotes dissociation of FLNA from ITGB3 and ITGB7. Promotes activation of integrins and regulates integrin-mediated cell-cell adhesion.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.