S1PR5 — Sphingosine-1-phosphate receptor 5
S1PR5 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
S1PR5's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Cytotoxic Effector Program cytotoxicity | APMAP, C16orf54, CST7, CTSW, EHD1, HLA-A, HLA-B, HLA-C +8 more | |
| Mucosal-associated invariant T cell | Chromatin Maintenance State DNA/chromatin regulation | ATRX, DYRK2, GART, KIF2A, PILRB, RBL2, SH2D1A, THEMIS2 +3 more |
About the gene
| Synonyms | Edg-8, EDG8 |
|---|---|
| Chromosome | 19: 10512742-10517931 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | FDA approved drug targets, G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | G-protein coupled receptor, Receptor, Transducer |
Function
Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins (By similarity). May play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.