CTSW — Cathepsin W
CTSW belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CTSW's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Cytotoxic effector Cytotoxicity | ADAM23, EMP3, FKBP2, IFITM2, IGFBP3, KLRG1, LYAR, PLP2 +11 more | View in SCUBA |
| Gamma-delta T cells | Cytotoxic Effector Program cytotoxicity | APMAP, C16orf54, CST7, EHD1, HLA-A, HLA-B, HLA-C, HLA-E +8 more | |
| Innate lymphoid cells | NK Homing Circulating Homing & TEM | ADD3, ANXA1, APOBEC3G, C16orf54, C1orf162, CAPG, CASP4, CAST +37 more | View in SCUBA |
| Natural Killer cells | NK Homing & Residency Homing & TEM | C11orf21, CD47, FXYD5, PRMT2, RIPOR2, S1PR4, SAMHD1, TFDP2 +2 more | View in SCUBA |
About the gene
| Chromosome | 11: 65879809-65883741 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Hydrolase, Protease, Thiol protease |
Function
May have a specific function in the mechanism or regulation of T-cell cytolytic activity. (Microbial infection) Plays a role during influenza virus infection in lungs cells ex vivo. Acts at the level of virus entering host cytoplasm from late endosome
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.