SH2D1A — SH2 domain containing 1A
SH2D1A belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SH2D1A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | T Cell Signaling B cell help | CCDC6, EFNB2, ELMO1, ETS1, MYO5A, PTPN11, RABGAP1L, SFXN1 +4 more | View in SCUBA |
| CD8⁺ T cells | Effector-Memory CD8 T cell maturation | CD27, CD44, CMC1, CST7, CXCR3, DUSP2, EOMES, F2R +8 more | View in SCUBA |
| Gamma-delta T cells | gd T Cell Identity T cell maturation | AKAP17A, CNNM3, GALNT11, KCNA3, MECP2, PIEZO1, PLXNC1, RASGEF1A +6 more | |
| Mucosal-associated invariant T cell | Chromatin Maintenance State DNA/chromatin regulation | ATRX, DYRK2, GART, KIF2A, PILRB, RBL2, S1PR5, THEMIS2 +3 more | |
| Natural Killer cells | NK Maturation Program Differentiation | ARPC5L, BAALC, CDHR1, EOMES, PDE7A, PDLIM1, S100PBP, TESC +2 more | View in SCUBA |
About the gene
| Synonyms | DSHP, EBVS, IMD5, LYP, MTCP1, SAP, XLP, XLPD |
|---|---|
| Chromosome | X: 124227868-124373197 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
| Biological process | Adaptive immunity, Immunity, Innate immunity |
Function
Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2. However, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1. Positively regulates CD244/2B4- and CD84-mediated natural killer (NK) cell functions. Can also promote CD48-, SLAMF6 -, LY9-, and SLAMF7-mediated NK cell activation. In the context of NK cell-mediated cytotoxicity enhances conjugate formation with target cells (By similarity). May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.