EHD1 — EH domain containing 1
EHD1 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
EHD1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Pol II Transcription Regulation DNA/chromatin regulation | ABHD5, BAIAP2, BRD2, CBX4, CDKN1C, CITED2, CKS2, EIF4A1 +28 more | View in SCUBA |
| Endothelial | Procoagulant TGF-β Response Inflammation | CITED4, CSF3, F3, LAMC1, LIPG, MED24, PLEKHO1, PMEPA1 +7 more | View in SCUBA |
| Gamma-delta T cells | Cytotoxic Effector Program cytotoxicity | APMAP, C16orf54, CST7, CTSW, HLA-A, HLA-B, HLA-C, HLA-E +8 more | |
| Innate lymphoid cells | Dissociation Stress Response Stress | C12orf57, CA2, CALM2, EIF4A2, IER2, MEPCE, NDRG1, NUDT4 +9 more | View in SCUBA |
| Monocytes | Epigenetic Inflammatory Reprogramming Inflammatory | BHLHE40, KDM6B, PHACTR1, PLEK, PPIF, SMAD7, SOD2, ZNF267 | View in SCUBA |
| Mucosal-associated invariant T cell | Retinoic Acid Response Tissue residence | C16orf54, CHRAC1, MRPL10, NDRG1, PERP, RALGDS, RARA | |
| Neutrophils | NF-κB Activation Inflammatory | GRAMD1A, NBN, NFKB2, NFKBIA, NFKBIZ, PLAUR, PLEK, PLK3 +6 more |
About the gene
| Synonyms | FLJ42622, FLJ44618, H-PAST, HPAST1, PAST1 |
|---|---|
| Chromosome | 11: 64851642-64888296 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins, Transporters |
| Biological process | Cilium biogenesis/degradation, Protein transport, Transport |
Function
ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. In vitro causes vesiculation of endocytic membranes. Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Recruited to endosomal membranes upon nerve growth factor stimulation, indirectly regulates neurite outgrowth (By similarity). Plays a role in myoblast fusion (By similarity). Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing (By similarity). Plays a role in the formation of the ciliary vesicle (CV), an early step in cilium biogenesis. Proposed to be required for the fusion of distal appendage vesicles (DAVs) to form the CV by recruiting SNARE complex component SNAP29. Is required for recruitment of transition zone proteins CEP290, RPGRIP1L, TMEM67 and B9D2, and of IFT20 following DAV reorganization before Rab8-dependent ciliary membrane extension. Required for the loss of CCP110 form the mother centriole essential for the maturation of the basal body during ciliogenesis.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.